David Shapiro, M.D. has served as a member of our Board of Directors since March 2026. Dr. Shapiro previously served on the board of directors of Galecto Inc., now Damora Therapeutics, Inc., from May 2020 to November 2025 and Organovo Holdings, Inc. from December 2018 until July 2020. From 1998 to April 2024, Dr. Shapiro served as the President and Chief Executive Officer of Integrated Quality Resources, a biotechnology and pharmaceutical development consulting company. Dr. Shapiro served as Chief Medical Officer and head of R&D at Intercept Pharmaceuticals, Inc., a biopharmaceutical company, from April 2007 to May 2019. Earlier in his career, Dr. Shapiro was Chief Medical Officer, EVP Medical Affairs at Idun Pharmaceuticals, Inc., a biotechnology company which was acquired by Pfizer in 2005. Dr. Shapiro also served as President of the Scripps Medical Research Center at Scripps Clinic from 1995 to 1997 and has held senior appointments at several biotechnology companies. Prior to joining the biotechnology sector, he led Merck & Co. s hypertension clinical research program. Dr. Shapiro has served on the board of directors of several private companies and currently serves on the board of directors of Precision Biosciences, Inc. Dr. Shapiro holds an M.D. from Dundee University and Medical School and trained in general and respiratory medicine at the Oxford University Teaching Hospitals and the University of Vermont. He is a fellow of the Royal College of Physicians of London (FRCP) and is an FFPM and FAASLD. The Board of Directors believes that Dr. Shapiro is qualified to serve on our Board due to his significant experience as a director and executive experience with biotechnology companies.