Director Member, Nominating and Corporate Governance Committee Age: 82 Director since: 2003 The Board believes Dr. Friedman s business experience, including his experience as an executive officer at biopharmaceutical companies and a leading clinical and research center specializing in cancer and diabetes, and his service at the Food and Drug Administration, combined with his business acumen and judgment provide our Board with valuable scientific and operational expertise and leadership and Michael A. Friedman, M.D. has been one of our directors since December 2003. In 2014, Dr. Friedman completed a decade of service as the President and Chief Executive Officer of the City of Hope National Medical Center. Previously, Dr. Friedman held the position of Senior Vice President of Research and Development, Medical and Public Policy, for Pharmacia Corporation (September 2001-April 2003) and was a Senior Vice President of Searle , a subsidiary of Monsanto Company (July 1999-September 2001). Dr. Friedman served as Deputy Commissioner for Operations for the Food and Drug Administration (1995-1999), and was Acting Commissioner and Lead Deputy Commissioner (1997-1998). He served on the board of Celgene Corporation (2011-2019) and on the board of Smith & Nephew plc (2013-2019). Dr. Friedman received a Bachelor of Arts degree, magna cum laude, from Tulane University, New Orleans, Louisiana, and a doctorate in medicine from the University of Texas, Southwestern Medical School.