KRYSTAL BIOTECH INC (KRYS)

Sector: Health Care

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2026 Annual Meeting Analysis

KRYSTAL BIOTECH INC · Meeting: May 15, 2026

Policy v1.2high confidenceView Filing ↗
For informational purposes only. This AI-generated analysis applies a published voting policy to publicly available proxy filings. It does not constitute investment advice, proxy voting advice, or a solicitation of any kind. AI analysis may be incomplete or inaccurate — always review the actual filing and make your own independent decision.

Directors FOR

2

Directors AGAINST

0

Say on Pay

FOR

Auditor

FOR

Director Elections

Election of Class III Directors

2 FOR
✓ FOR
Krish S. Krishnan

Krystal's 3-year stock return of +226% outpaces the peer group median by +144 percentage points, far exceeding the 65-point threshold needed to trigger a concern, so the TSR test does not raise a flag; no overboarding, attendance, or independence issues were identified.

✓ FOR
Christopher Mason

Dr. Mason has served since January 2021 and brings deep gene and cell therapy expertise as the company's Science and Technology Committee chair; the TSR trigger does not apply given Krystal's strong outperformance of both its peer group and XBI (SPDR S&P Biotech ETF), and no other policy concerns were identified.

Both Class III nominees pass all policy screens. Krystal's 3-year stock return of +226% beats the disclosed peer group median by roughly 144 percentage points and beats XBI (SPDR S&P Biotech ETF) by roughly 158 percentage points — well above the 65-point threshold required to trigger a concern for a company with strong positive returns. Neither director is overboarded, attendance was at least 75%, and both bring relevant qualifications. Vote FOR both nominees.

Say on Pay

✓ FOR

CEO

Krish S. Krishnan

Total Comp

$10,442,485

Prior Support

96%%

The CEO's total pay of approximately $10.4 million is reasonable for a biotechnology company of Krystal's size (~$7.6 billion market cap) that delivered $389 million in product revenue and a 3-year stock return of +226%, dramatically outperforming XBI (SPDR S&P Biotech ETF) by roughly 158 percentage points. Pay structure is heavily weighted toward variable, at-risk compensation — the company reports approximately 85% of the CEO's total pay is variable — satisfying the policy requirement that at least 50-60% be performance-linked. The program received over 96% shareholder support at the prior annual meeting, the company has a formal clawback policy in place, and the pay-for-performance alignment is strong given the company's exceptional stock performance and commercial milestones.

Auditor Ratification

✓ FOR

Auditor

KPMG LLP

Tenure

N/A

Audit Fees

$955,000

Non-Audit Fees

$23,625

Non-audit fees (tax consulting of $23,625) represent only about 2.5% of audit fees ($955,000), well below the 50% threshold that would raise independence concerns; auditor tenure is not disclosed so no tenure trigger fires; KPMG is a Big 4 firm appropriate for a $7.6 billion market-cap company; all services were pre-approved by the Audit Committee.

Stockholder Proposals

1 proposal submitted by shareholders

Proposal 4

Approval of the Non-Employee Director Compensation Policy

✓ FOR
Filed by:Board of Directors (management proposal)OtherGovernance
Board recommends: FOR
settlement of derivative litigation alleging excessive prior director paystockholder vote excludes shares held by non-employee directors and litigation defendantscompensation capped at 75th percentile of peer group without further shareholder approval through 2030

This proposal asks shareholders to approve a formal non-employee director compensation policy that was developed as part of the settlement of a Delaware lawsuit alleging that prior director pay was excessive; the policy sets 2026 pay at the 50th percentile of a disclosed peer group (annual equity awards of $400,000 per director) and caps future years at the 75th percentile without requiring further shareholder votes through 2030. The settlement structure — which requires both shareholder approval and court approval to become effective, and which excludes director votes from the tally — provides meaningful checks on potential self-dealing. While the board retaining discretion to increase pay up to the 75th percentile without future votes is a modest governance concession, the overall package represents a clear improvement over the prior unconstrained pay practice and is the product of arms-length litigation, making it appropriate to support.

Overall Assessment

The 2026 Krystal Biotech annual meeting presents a straightforward ballot with no significant governance red flags: the company has delivered exceptional shareholder returns over three years (+226% versus +68% for XBI, the SPDR S&P Biotech ETF), executive pay is heavily performance-linked and received 96% shareholder support last year, KPMG's non-audit fees are minimal, and the director compensation policy proposal is supported by a settlement framework that imposes meaningful constraints on future pay. All four proposals merit a FOR vote.

Filing date: April 3, 2026·Policy v1.2·high confidence

Compensation Peer Group

17 companies disclosed in 2026 proxy filing

APLSApellis Pharmaceuticals
BPMCBlueprint Medicines
BBIOBridgeBio Pharma
CPRXCatalyst Pharmaceuticals
CORTCorcept Therapeutics
GERNGeron Corporation
HALOHalozyme Therapeutics
INSMInsmed Incorporated
ITCIIntra-Cellular Therapies
IONSIonis Pharmaceuticals
IOVAIovance Biotherapeutics
MDGLMadrigal Pharmaceuticals
RYTMRhythm Pharmaceuticals
SWTXSpringWorks Therapeutics
TGTXTG Therapeutics
RAREUltragenyx Pharmaceutical
VCELVericel Corporation